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pentobarbital will minimize the level or result of tamoxifen by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use warning/check. pentobarbital will decrease the level or result of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use warning/watch. sturdy CYP3A4 inducers may lower suvorexant efficacy; if enhanced suvo